The CRONIC-PPF Faculty

	Thomas BÄRNTHALER Ass.-Prof. Priv.-Doz. Dr.med.univ. PhD Peripheral blood signatures of antifibrotics in patients with progressive pulmonary fibrosis
Head of Research Unit "Molecular Pharmacology in Pulmonary Diseases" Division of Pharmacology, Otto Loewi Research Centre, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz Phone: +43-316-385 74106, ✉ e-mail WWW: Forschungsportal Med Uni Graz ORCID: 0000-0002-4988-3700 PubMed: PubMed (nih.gov)
• Profile      • Curriculum vitae     • Publications

List of publications:

• For a full list of publications see → Fodok Med Uni Graz

10 most significant publications:

1. Bärnthaler T, Theiler A, Zabini D, Trautmann S, Stacher-Priehse E, Lanz I, Klepetko W, Sinn K, Flick H, Scheidl S, Thomas D, Olschewski H, Kwapiszewska G, Schuligoi R, Heinemann A: Inhibiting eicosanoid degradation exerts antifibrotic effects in a pulmonary fibrosis mouse model and human tissue. J Allergy Clin Immunol, 2020; 145(3):​818–833.e11.
2. Rajesh R, Mooslechner AA, Schweighofer H, Pahernik S, Lanz I, Atallah R, Platzer W, Aigner C, Benazzo A, Angiari S, Marsh L, Kwapiszewska G, Heinemann A, Bärnthaler T: Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis. Am J Physiol Lung Cell Mol Physiol, 2025; 328(5):​L671–L684.
3. Bärnthaler T, Jandl K, Sill H, Uhl B, Schreiber Y, Grill M, Thomas D, Schicho R, Marsche G, Frank S, Heinemann A, Schuligoi R: Imatinib stimulates prostaglandin E₂ and attenuates cytokine release via EP4 receptor activation. J Allergy Clin Immunol, 2019; 143(2):​794–797.e10.
4. Bärnthaler T, Maric J, Platzer W, Konya V, Theiler A, Hasenöhrl C, Gottschalk B, Trautmann S, Schreiber Y, Graier WF, Schicho R, Marsche G, Olschewski A, Thomas D, Schuligoi R, Heinemann A: The Role of PGE₂ in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk. Sci Rep, 2017; 7(1):​7923.
5. Ahangari F, Price NL, Malik S, Chioccioli M, Bärnthaler T, Adams TS, Kim J, Pradeep SP, Ding S, Cosmos C Jr, Rose KS, McDonough JE, Aurelien NR, Ibarra G, Omote N, Schupp JC, DeIuliis G, Villalba Nunez JA, Sharma L, Ryu C, Dela Cruz CS, Liu X, Prasse A, Rosas I, Bahal R, Fernández-Hernando C, Kaminski N: microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight, 2023; 8(4):​e158100.
6. Theiler A, Bärnthaler T, Platzer W, Richtig G, Peinhaupt M, Rittchen S, Kargl J, Ulven T, Marsh LM, Marsche G, Schuligoi R, Sturm EM, Heinemann A: Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival. J Allergy Clin Immunol, 2019; 144(3):​764–776.
7. Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP: Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmo-nary Fibrosis. Am J Respir Crit Care Med, 2022; 206(12):​1463–1479.
8. Schoerghuber M, Bärnthaler T, Prüller F, Mantaj P, Cvirn G, Toller W, Klivinyi C, Mahla E, Heinemann A: Supplemental fibrinogen restores thrombus formation in cardiopulmonary bypass-induced platelet dysfunction ex vivo. Br J Anaesth, 2023; 131(3):​452–462.
9. Rajesh R, Atallah R, Bärnthaler T: Dysregulation of metabolic pathways in pulmonary fibrosis. Pharmacol Ther, 2023; 246:​108436.
10. Bärnthaler T, Ramachandra AB, Ebanks S, Guerrera N, Sharma L, Dela Cruz CS, Humphrey JD, Manning EP: Developmental changes in lung function of mice are independent of sex as a biological variable. Am J Physiol Lung Cell Mol Physiol, 2024; 326(5):​L627–L637.

04.04.2026 CRONIC-PPF · Doctoral Programme “Clinical & Research Oriented Network for Innovative Classification of Progressive Pulmonary Fibrosis”