The CRONIC-PPF Faculty

	Julia KARGL (former STURM) Assoz. Prof. Priv.-Doz. Mag. rer. nat. PhD The CCL20-dependent fibrotic niche: interactions between ATII cells, fibroblasts and immune cells
Deputy Chair of the Division of Pharmacology, Otto Loewi Research Center Division of Pharmacology, Otto Loewi Research Centre, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz Phone: +43-316-385 74105, ✉ e-mail WWW: Forschungsportal Med Uni Graz ORCID: 0000-0002-0870-0816 PubMed: PubMed (nih.gov)
• Profile      • Curriculum vitae     • Publications

List of publications:

• For a full list of publications see → Fodok Med Uni Graz

10 most significant publications:

1. Zotta A, Toller-Kawahisa J, Palsson-McDermott EM, O'Carroll SM, Henry ÓC, Day EA, McGettrick AF, Ward RW, Ryan DG, Watson MA, Brand MD, Runtsch MC, Maitz K, Lueger A, Kargl J, Miljkovic JL, Lavelle EC, O'Neill LAJ: Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion. Sci Adv, 2025; 11(4):​eadq7307.
2. Maitz K, Valadez-Cosmes P, Raftopoulou S, Kindler O, Kienzl M, Bolouri H, Houghton AM, Schicho R, Heinemann A, Kargl J: Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma. Cancers (Basel), 2023; 15(24):​5767.
3. Valadez-Cosmes P, Maitz K, Kindler O, Cosic Mujkanovic N, Lueger A, Raftopoulou S, Kienzl M, Mihalic Z, Santiso A, Sarsembayeva A, Brcic L, Lindenmann J, Sattler W, Heinemann A, Schicho R, Marsche G, Houghton AM, Kargl J: Myeloperoxidase promotes a tumorigenic microenvironment in non-small cell lung cancer. bioRxiv, 2023; 2023.01.28.526014.
4. Mihalic ZN, Kloimböck T, Cosic-Mujkanovic N, Valadez-Cosmes P, Maitz K, Kindler O, Wadsack C, Hei-nemann A, Marsche G, Gauster M, Pollheimer J, Kargl J: Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells. Redox Biol, 2023; 67:​102885.
5. Cosic-Mujkanovic N, Valadez-Cosmes P, Maitz K, Lueger A, Mihalic ZN, Runtsch MC, Kienzl M, Davies MJ, Chuang CY, Heinemann A, Schicho R, Marsche G, Kargl J: Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their Survival. Antioxidants (Basel), 2023; 12(8):​1587.
6. Zhang H, Zhu X, Friesen TJ, Kwak JW, Pisarenko T, Mekvanich S, Velasco MA, Randolph TW, Kargl J, Houghton AM: Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils. J Clin Invest, 2022; 132(22):​e153643.
7. Kienzl M, Hasenoehrl C, Maitz K, Sarsembayeva A, Taschler U, Valadez-Cosmes P, Kindler O, Ristic D, Raftopoulou S, Santiso A, Bärnthaler T, Brcic L, Hahnefeld L, Gurke R, Thomas D, Geisslinger G, Kargl J, Schicho R: Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. Oncoimmunology, 2021; 10(1):​1965319.
8. Valadez-Cosmes P, Maitz K, Kindler O, Raftopoulou S, Kienzl M, Santiso A, Mihalic ZN, Brcic L, Lindenmann J, Fediuk M, Pichler M, Schicho R, Houghton AM, Heinemann A, Kargl J: Identification of Novel Low-Density Neutrophil Markers Through Unbiased High-Dimensional Flow Cytometry Screening in Non-Small Cell Lung Cancer Patients. Front Immunol, 2021; 12:​703846.
9. Kargl J, Zhu X, Zhang H, Yang GHY, Friesen TJ, Shipley M, Maeda DY, Zebala JA, McKay-Fleisch J, Meredith G, Mashadi-Hossein A, Baik C, Pierce RH, Redman MW, Thompson JC, Albelda SM, Bolouri H, Houghton AM: Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC. JCI Insight, 2019; 4(24):​e130850.
10. Kargl J, Busch SE, Yang GH, Kim KH, Hanke ML, Metz HE, Hubbard JJ, Lee SM, Madtes DK, McIntosh MW, Houghton AM: Neutrophils dominate the immune cell composition in non-small cell lung cancer. Nat Commun, 2017; 8(5):​14381–14381.

05.04.2026 CRONIC-PPF · Doctoral Programme “Clinical & Research Oriented Network for Innovative Classification of Progressive Pulmonary Fibrosis”