The CRONIC-PPF Faculty

	Leigh MARSH Priv.-Doz. Dr. biol. hum. Resolution of pulmonary fibrosis via immune cell reprogramming
Assistant Professor at the Otto Loewi Research Center, Lung Research Group, Head of Research Unit "Immune Cell Interaction" Ludwig Boltzmann Institute for Lung Vascular Research, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz Phone: +43-316-385 72911, ✉ e-mail WWW: Forschungsportal Med Uni Graz ORCID: 0000-0002-1754-9249 PubMed: PubMed (nih.gov)
• Profile      • Curriculum vitae     • Publications

List of publications:

• For a full list of publications see → Fodok Med Uni Graz

10 most significant publications:

1. Bordag, N; Jandl, K; Syarif, AH; Gindlhuber, J; Schnoegl, D; Mutgan, AC; Foris, V; Hoetzenecker, K; Boehm, PM; Breyer-Kohansal, R; Zeder, K; Gorkiewicz, G; Polverino, F; Crnkovic, S; Kwapiszewska, G; Marsh, LM: Machine learning assisted immune profiling of COPD identifies a unique emphysema subtype independent of GOLD stage. iScience, 2025; 28(7):​112966.
2. Borek I, Birnhuber A, Voelkel NF, Marsh LM, Kwapiszewska G: The vascular perspective on acute and chronic lung disease. J Clin Invest, 2023; 133(16):​e170502.
3. Crnkovic S, Valzano F, Fließer E, Gindlhuber J, Thekkekara Puthenparampil H, Basil M, Morley MP, Katzen J, Gschwandtner E, Klepetko W, Cantu E, Wolinski H, Olschewski H, Lindenmann J, Zhao YY, Morrisey EE, Marsh LM, Kwapiszewska G: Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling. JCI Insight, 2022; 7(20):​e153471.
4. Jandl K, Marsh LM, Mutgan AC, Crnkovic S, Valzano F, Zabini D, Hoffmann J, Foris V, Gschwandtner E, Klepetko W, Prosch H, Flick H, Brcic L, Kern I, Heinemann A, Olschewski H, Kovacs G, Kwapiszewska G: Impairment of the NKT-STAT1-CXCL9 Axis Contributes to Vessel Fibrosis in Pulmonary Hypertension Caused by Lung Fibrosis. Am J Respir Crit Care Med, 2022; 206(8):​981–998.
5. Hochgerner M, Sturm EM, Schnoegl D, Kwapiszewska G, Olschewski H, Marsh LM: Low oxygen levels decrease adaptive immune responses and ameliorate experimental asthma in mice. Allergy, 2022; 77(3):​870–882.
6. Bordag N, Biasin V, Schnoegl D, Valzano F, Jandl K, Nagy BM, Sharma N, Wygrecka M, Kwapiszewska G, Marsh LM: Machine Learning Analysis of the Bleomycin Mouse Model Reveals the Compartmental and Temporal Inflammatory Pulmonary Fingerprint. iScience, 2020; 23(12):​101819.
7. Theiler A, Bärnthaler T, Platzer W, Richtig G, Peinhaupt M, Rittchen S, Kargl J, Ulven T, Marsh LM, Marsche G, Schuligoi R, Sturm EM, Heinemann A: Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival. J Allergy Clin Immunol, 2019; 144(3):​764–776.
8. Marsh LM, Jandl K, Grünig G, Foris V, Bashir M, Ghanim B, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G: The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension. Eur Respir J, 2018; 51(1):​1701214.
9. Zabini D, Crnkovic S, Xu H, Tscherner M, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G, Marsh LM: High-mobility group box-1 induces vascular remodelling processes via c-Jun activation. J Cell Mol Med, 2015; 19(5):​1151–1161.
10. Marsh LM, Cakarova L, Kwapiszewska G, von Wulffen W, Herold S, Seeger W, Lohmeyer J: Surface expression of CD74 by type II alveolar epithelial cells: a potential mechanism for macrophage migration inhibitory factor-induced epithelial repair. Am J Physiol Lung Cell Mol Physiol, 2009; 296(3): L442-L452.

03.04.2026 CRONIC-PPF · Doctoral Programme “Clinical & Research Oriented Network for Innovative Classification of Progressive Pulmonary Fibrosis”